Review





Similar Products

oxford x max jeol jib 4601f multibeam fib sem  (JEOL)
96
JEOL oxford x max jeol jib 4601f multibeam fib sem
Oxford X Max Jeol Jib 4601f Multibeam Fib Sem, supplied by JEOL, used in various techniques. Bioz Stars score: 96/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/oxford x max jeol jib 4601f multibeam fib sem/product/JEOL
Average 96 stars, based on 1 article reviews
oxford x max jeol jib 4601f multibeam fib sem - by Bioz Stars, 2026-05
96/100 stars
  Buy from Supplier
sta liquid fib reagent  (Diagnostica Stago)
86
Diagnostica Stago sta liquid fib reagent
Sta Liquid Fib Reagent, supplied by Diagnostica Stago, used in various techniques. Bioz Stars score: 86/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/sta liquid fib reagent/product/Diagnostica Stago
Average 86 stars, based on 1 article reviews
sta liquid fib reagent - by Bioz Stars, 2026-05
86/100 stars
  Buy from Supplier
field emission scanning electron microscopy fe sem  (JEOL)
95
JEOL field emission scanning electron microscopy fe sem
Field Emission Scanning Electron Microscopy Fe Sem, supplied by JEOL, used in various techniques. Bioz Stars score: 95/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/field emission scanning electron microscopy fe sem/product/JEOL
Average 95 stars, based on 1 article reviews
field emission scanning electron microscopy fe sem - by Bioz Stars, 2026-05
95/100 stars
  Buy from Supplier
jeol jib 4610f instrument  (JEOL)
95
JEOL jeol jib 4610f instrument
Jeol Jib 4610f Instrument, supplied by JEOL, used in various techniques. Bioz Stars score: 95/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/jeol jib 4610f instrument/product/JEOL
Average 95 stars, based on 1 article reviews
jeol jib 4610f instrument - by Bioz Stars, 2026-05
95/100 stars
  Buy from Supplier
fak inhibitor 14 fib 14  (Tocris)
93
Tocris fak inhibitor 14 fib 14
A) U2OS cells were infected with TCRV (MOI=1) for 5 or 15 minutes. Western blots were probed with phospho-FAK (Y397) antibody. U, uninfected. B) U2OS cells were treated <t>with</t> <t>FIB-14</t> for 1 hour and western blots were probed phospho-FAK (Y397) antibody. C) U2OS were treated with FIB-14 and infected with the indicated viruses. RNA was isolated at 24 hpi. Shown is the average ± SD of 3 (TCRV, JUNV C1) or 2 (LCMV) independent experiments. Student’s T test was used to determine significance. **, P ≤ 0.01; ****, P ≤ 0.0001. D) U2OS cells were treated with FIB-14 and infected with MACV, or VSV G pseudoviruses. Luciferase assays were performed at 48 hpi. Shown is the average ± SD of 3 independent experiments. One-way ANOVA was used to determine significance. ****, P ≤ 0.0001. E) shSIRPA or shCTRL cells were treated with FIB-14 and infected with the indicated viruses. RNA was isolated at 24 hpi. Shown is the average ± SD of 3 independent experiments. One-way ANOVA was used to determine significance. ***, P ≤ 0.001; ****, P ≤ 0.0001. F) VIAs were carried out with U2OS cells treated with FIB-14. Internalized viral RNA was analyzed by RT-qPCR. Shown is the average ± SD of 3 independent experiments. Student’s T test was used to determine significance. *, P ≤ 0.05; **, P ≤ 0.01.
Fak Inhibitor 14 Fib 14, supplied by Tocris, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/fak inhibitor 14 fib 14/product/Tocris
Average 93 stars, based on 1 article reviews
fak inhibitor 14 fib 14 - by Bioz Stars, 2026-05
93/100 stars
  Buy from Supplier
jeol jib  (JEOL)
95
JEOL jeol jib
A) U2OS cells were infected with TCRV (MOI=1) for 5 or 15 minutes. Western blots were probed with phospho-FAK (Y397) antibody. U, uninfected. B) U2OS cells were treated <t>with</t> <t>FIB-14</t> for 1 hour and western blots were probed phospho-FAK (Y397) antibody. C) U2OS were treated with FIB-14 and infected with the indicated viruses. RNA was isolated at 24 hpi. Shown is the average ± SD of 3 (TCRV, JUNV C1) or 2 (LCMV) independent experiments. Student’s T test was used to determine significance. **, P ≤ 0.01; ****, P ≤ 0.0001. D) U2OS cells were treated with FIB-14 and infected with MACV, or VSV G pseudoviruses. Luciferase assays were performed at 48 hpi. Shown is the average ± SD of 3 independent experiments. One-way ANOVA was used to determine significance. ****, P ≤ 0.0001. E) shSIRPA or shCTRL cells were treated with FIB-14 and infected with the indicated viruses. RNA was isolated at 24 hpi. Shown is the average ± SD of 3 independent experiments. One-way ANOVA was used to determine significance. ***, P ≤ 0.001; ****, P ≤ 0.0001. F) VIAs were carried out with U2OS cells treated with FIB-14. Internalized viral RNA was analyzed by RT-qPCR. Shown is the average ± SD of 3 independent experiments. Student’s T test was used to determine significance. *, P ≤ 0.05; **, P ≤ 0.01.
Jeol Jib, supplied by JEOL, used in various techniques. Bioz Stars score: 95/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/jeol jib/product/JEOL
Average 95 stars, based on 1 article reviews
jeol jib - by Bioz Stars, 2026-05
95/100 stars
  Buy from Supplier
plastic strains  (JEOL)
96
JEOL plastic strains
A) U2OS cells were infected with TCRV (MOI=1) for 5 or 15 minutes. Western blots were probed with phospho-FAK (Y397) antibody. U, uninfected. B) U2OS cells were treated <t>with</t> <t>FIB-14</t> for 1 hour and western blots were probed phospho-FAK (Y397) antibody. C) U2OS were treated with FIB-14 and infected with the indicated viruses. RNA was isolated at 24 hpi. Shown is the average ± SD of 3 (TCRV, JUNV C1) or 2 (LCMV) independent experiments. Student’s T test was used to determine significance. **, P ≤ 0.01; ****, P ≤ 0.0001. D) U2OS cells were treated with FIB-14 and infected with MACV, or VSV G pseudoviruses. Luciferase assays were performed at 48 hpi. Shown is the average ± SD of 3 independent experiments. One-way ANOVA was used to determine significance. ****, P ≤ 0.0001. E) shSIRPA or shCTRL cells were treated with FIB-14 and infected with the indicated viruses. RNA was isolated at 24 hpi. Shown is the average ± SD of 3 independent experiments. One-way ANOVA was used to determine significance. ***, P ≤ 0.001; ****, P ≤ 0.0001. F) VIAs were carried out with U2OS cells treated with FIB-14. Internalized viral RNA was analyzed by RT-qPCR. Shown is the average ± SD of 3 independent experiments. Student’s T test was used to determine significance. *, P ≤ 0.05; **, P ≤ 0.01.
Plastic Strains, supplied by JEOL, used in various techniques. Bioz Stars score: 96/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/plastic strains/product/JEOL
Average 96 stars, based on 1 article reviews
plastic strains - by Bioz Stars, 2026-05
96/100 stars
  Buy from Supplier
retractable detector  (JEOL)
96
JEOL retractable detector
A) U2OS cells were infected with TCRV (MOI=1) for 5 or 15 minutes. Western blots were probed with phospho-FAK (Y397) antibody. U, uninfected. B) U2OS cells were treated <t>with</t> <t>FIB-14</t> for 1 hour and western blots were probed phospho-FAK (Y397) antibody. C) U2OS were treated with FIB-14 and infected with the indicated viruses. RNA was isolated at 24 hpi. Shown is the average ± SD of 3 (TCRV, JUNV C1) or 2 (LCMV) independent experiments. Student’s T test was used to determine significance. **, P ≤ 0.01; ****, P ≤ 0.0001. D) U2OS cells were treated with FIB-14 and infected with MACV, or VSV G pseudoviruses. Luciferase assays were performed at 48 hpi. Shown is the average ± SD of 3 independent experiments. One-way ANOVA was used to determine significance. ****, P ≤ 0.0001. E) shSIRPA or shCTRL cells were treated with FIB-14 and infected with the indicated viruses. RNA was isolated at 24 hpi. Shown is the average ± SD of 3 independent experiments. One-way ANOVA was used to determine significance. ***, P ≤ 0.001; ****, P ≤ 0.0001. F) VIAs were carried out with U2OS cells treated with FIB-14. Internalized viral RNA was analyzed by RT-qPCR. Shown is the average ± SD of 3 independent experiments. Student’s T test was used to determine significance. *, P ≤ 0.05; **, P ≤ 0.01.
Retractable Detector, supplied by JEOL, used in various techniques. Bioz Stars score: 96/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/retractable detector/product/JEOL
Average 96 stars, based on 1 article reviews
retractable detector - by Bioz Stars, 2026-05
96/100 stars
  Buy from Supplier
jib 4601f sem  (JEOL)
96
JEOL jib 4601f sem
A) U2OS cells were infected with TCRV (MOI=1) for 5 or 15 minutes. Western blots were probed with phospho-FAK (Y397) antibody. U, uninfected. B) U2OS cells were treated <t>with</t> <t>FIB-14</t> for 1 hour and western blots were probed phospho-FAK (Y397) antibody. C) U2OS were treated with FIB-14 and infected with the indicated viruses. RNA was isolated at 24 hpi. Shown is the average ± SD of 3 (TCRV, JUNV C1) or 2 (LCMV) independent experiments. Student’s T test was used to determine significance. **, P ≤ 0.01; ****, P ≤ 0.0001. D) U2OS cells were treated with FIB-14 and infected with MACV, or VSV G pseudoviruses. Luciferase assays were performed at 48 hpi. Shown is the average ± SD of 3 independent experiments. One-way ANOVA was used to determine significance. ****, P ≤ 0.0001. E) shSIRPA or shCTRL cells were treated with FIB-14 and infected with the indicated viruses. RNA was isolated at 24 hpi. Shown is the average ± SD of 3 independent experiments. One-way ANOVA was used to determine significance. ***, P ≤ 0.001; ****, P ≤ 0.0001. F) VIAs were carried out with U2OS cells treated with FIB-14. Internalized viral RNA was analyzed by RT-qPCR. Shown is the average ± SD of 3 independent experiments. Student’s T test was used to determine significance. *, P ≤ 0.05; **, P ≤ 0.01.
Jib 4601f Sem, supplied by JEOL, used in various techniques. Bioz Stars score: 96/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/result/jib 4601f sem/product/JEOL
Average 96 stars, based on 1 article reviews
jib 4601f sem - by Bioz Stars, 2026-05
96/100 stars
  Buy from Supplier

Image Search Results


A) U2OS cells were infected with TCRV (MOI=1) for 5 or 15 minutes. Western blots were probed with phospho-FAK (Y397) antibody. U, uninfected. B) U2OS cells were treated with FIB-14 for 1 hour and western blots were probed phospho-FAK (Y397) antibody. C) U2OS were treated with FIB-14 and infected with the indicated viruses. RNA was isolated at 24 hpi. Shown is the average ± SD of 3 (TCRV, JUNV C1) or 2 (LCMV) independent experiments. Student’s T test was used to determine significance. **, P ≤ 0.01; ****, P ≤ 0.0001. D) U2OS cells were treated with FIB-14 and infected with MACV, or VSV G pseudoviruses. Luciferase assays were performed at 48 hpi. Shown is the average ± SD of 3 independent experiments. One-way ANOVA was used to determine significance. ****, P ≤ 0.0001. E) shSIRPA or shCTRL cells were treated with FIB-14 and infected with the indicated viruses. RNA was isolated at 24 hpi. Shown is the average ± SD of 3 independent experiments. One-way ANOVA was used to determine significance. ***, P ≤ 0.001; ****, P ≤ 0.0001. F) VIAs were carried out with U2OS cells treated with FIB-14. Internalized viral RNA was analyzed by RT-qPCR. Shown is the average ± SD of 3 independent experiments. Student’s T test was used to determine significance. *, P ≤ 0.05; **, P ≤ 0.01.

Journal: bioRxiv

Article Title: SIRPA suppresses integrin-dependent virus endocytosis

doi: 10.64898/2026.04.17.719277

Figure Lengend Snippet: A) U2OS cells were infected with TCRV (MOI=1) for 5 or 15 minutes. Western blots were probed with phospho-FAK (Y397) antibody. U, uninfected. B) U2OS cells were treated with FIB-14 for 1 hour and western blots were probed phospho-FAK (Y397) antibody. C) U2OS were treated with FIB-14 and infected with the indicated viruses. RNA was isolated at 24 hpi. Shown is the average ± SD of 3 (TCRV, JUNV C1) or 2 (LCMV) independent experiments. Student’s T test was used to determine significance. **, P ≤ 0.01; ****, P ≤ 0.0001. D) U2OS cells were treated with FIB-14 and infected with MACV, or VSV G pseudoviruses. Luciferase assays were performed at 48 hpi. Shown is the average ± SD of 3 independent experiments. One-way ANOVA was used to determine significance. ****, P ≤ 0.0001. E) shSIRPA or shCTRL cells were treated with FIB-14 and infected with the indicated viruses. RNA was isolated at 24 hpi. Shown is the average ± SD of 3 independent experiments. One-way ANOVA was used to determine significance. ***, P ≤ 0.001; ****, P ≤ 0.0001. F) VIAs were carried out with U2OS cells treated with FIB-14. Internalized viral RNA was analyzed by RT-qPCR. Shown is the average ± SD of 3 independent experiments. Student’s T test was used to determine significance. *, P ≤ 0.05; **, P ≤ 0.01.

Article Snippet: BTT-3033 and FAK inhibitor 14 (FIB-14) were purchased from TOCRIS, LHF-535 and favipiravir (6-fluoro-3-hydroxy-2-pyrazinecarboxamide) from TargetMol Chemicals and PP1 from Cayman Chemical.

Techniques: Infection, Western Blot, Isolation, Luciferase, Quantitative RT-PCR

This step is inhibited by integrin inhibitors such as BT-3033 and the FAK inhibitor FIB-14. When virus binds to cells, an unknown signal also triggers Fyn to phosphorylate tyrosine residues in SIRPA’s ITIM region. This step is inhibited by SRC family inhibitors like PP1. SIRPA phosphorylation recruits and activates SHP2, which in turn dephosphorylates signaling molecules in the integrin signaling pathway like FAK and NMII. The dephosphorylation of integrin pathway components negatively impacts cytoskeletal rearrangement and actin polymerization, thereby reducing viral internalization. Originally created in BioRender. Yan, M. (2024) BioRender.com/h75b068 and modified by Ross, S. (2026) https://BioRender.com/ ooyrvzl.

Journal: bioRxiv

Article Title: SIRPA suppresses integrin-dependent virus endocytosis

doi: 10.64898/2026.04.17.719277

Figure Lengend Snippet: This step is inhibited by integrin inhibitors such as BT-3033 and the FAK inhibitor FIB-14. When virus binds to cells, an unknown signal also triggers Fyn to phosphorylate tyrosine residues in SIRPA’s ITIM region. This step is inhibited by SRC family inhibitors like PP1. SIRPA phosphorylation recruits and activates SHP2, which in turn dephosphorylates signaling molecules in the integrin signaling pathway like FAK and NMII. The dephosphorylation of integrin pathway components negatively impacts cytoskeletal rearrangement and actin polymerization, thereby reducing viral internalization. Originally created in BioRender. Yan, M. (2024) BioRender.com/h75b068 and modified by Ross, S. (2026) https://BioRender.com/ ooyrvzl.

Article Snippet: BTT-3033 and FAK inhibitor 14 (FIB-14) were purchased from TOCRIS, LHF-535 and favipiravir (6-fluoro-3-hydroxy-2-pyrazinecarboxamide) from TargetMol Chemicals and PP1 from Cayman Chemical.

Techniques: Virus, Phospho-proteomics, De-Phosphorylation Assay, Modification